The effectiveness and cost of lansoprazole and pantoprazole for stress ulcer prophylaxis in intensive care unit

The incidence of bleeding is increased in high risk patients with critical conditions Intensive Care Unit (ICU). Appropriate prophylaxis medicine necessary to reduce the stress ulcer during hospitalization ICU which further can minimize cost patient care ICU. Currently, lansoprazole and pantoprazole are used as a ulcers prophylaxis. Nevertheless, there has not been sufficient evidence proving their effectiveness. This study was aimed compare effectiveness between iv In this retrospective observational study, data were obtained from medical records all admitted District Hospital Yogyakarta January 2014 until December 2016. Effectiveness therapy objective record by looking at major (clinically significant) minor (overt gastrointestinal) bleeding. Chi-square analysis performed analyze difference incidence. average presented Expected Monetary Value (EMV), consisted treatment analyzed using independent t-test. A total 119 included study. There 62 group 47 group. Forty eight (77,4%) 35 (61,4%) did experience any GI no statistical two groups (CI 95%, P-value = 0.057). EMV higher than IDR 645.122,57 511.629,39 respectively. conclusion, significant regarding Costs for lower on use compared lansoprazole.